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A January 2008 article in a new journal Future HIV Therapy<\/a> makes the most persuasive case for male circumcision being rolled out on a much, much wider scale in sub-Saharan Africa. We have blogged about the importance of male circumcision before (see here<\/a>, here<\/a>, and here<\/a>).<\/p>\n This new piece is by Jeffrey D Klausner, Richard G Wamai, Kasonde Bowa, Kawango Agot, Jesse Kagimba & Daniel T Halperin. They start their paper by asking “What would the reaction of the international public health community have been if a year ago scientists had announced the discovery of a vaccine or chemical gel that, in three separate clinical trials, had reduced the risk of heterosexual HIV infection in men by at least 60%?”<\/p>\n They answer that question by noting that male circumcision (MC) provides that kind of risk reduction potential and also one which potentially provides an “\u2018African solution to African problems.”<\/p>\n Here are some choice quotes:<\/p>\n Currently, MC is the only modality for preventing sexual HIV transmission that has been proven to work by the highest standards of scientific evidence; specifically, findings from multiple randomized controlled trials. In fact, it appears that the actual protective effect of MC is probably somewhat higher than the official 60% estimate cited by WHO and UNAIDS, especially among higher-risk men.<\/p>\n In fact, it appears that the actual protective effect of MC is probably somewhat higher than the official 60% estimate cited by WHO and UNAIDS, especially among higher-risk men. In part, this is because some men who were randomly assigned to the circumcision arm in each trial did not show up for their appointment and, more importantly, a larger number of men who were randomly assigned to noncircumcision decided to get circumcised on their own during the trial period. Hence, the \u2018as-treated\u2019 protective effect, taking into account the actual MC status of participants, was a 76% HIV reduction in the trial in South Africa (where HIV prevalence was highest) [19]; and averaging across the three trials it was 65% [12].<\/p>\n The ultimate population-level impact of MC would be further amplified by a \u2018herd immunity\u2019 phenomenon if a sufficiently large proportion of men were to become circumcised in the population.<\/p>\n Modeling suggests that widespread circumcision in the rest of sub-Saharan Africa could avert up to 2 million new HIV cases and 300,000 deaths over the next 10 years, and 3.7 million infections and 2.7 million deaths in the following 10 years, many of those among women [27].<\/p><\/blockquote>\n What about the cultural acceptability of male circumcision? Is this not cultural imperialism? This article largely puts that notion to bed.<\/p>\n A dozen acceptability studies conducted in different parts of Africa where MC is no longer traditionally practiced have found that the majority of uncircumcised men want the procedure performed, and generally an even higher proportion of women in those regions would prefer to have an circumcised partner.<\/p>\n Male circumcision was historically practiced in nearly all of Africa, but 19th century European missionaries condemned the widespread traditional initiation ceremonies, which included circumcision, as pagan practices.<\/p>\n In a 2006 household survey of Swazi men in both urban and rural areas, 87% said they would want the procedure if it helped reduce the risk of HIV infection. In January of that year, the media reported on a \u2018circumcision riot\u2019 when over a hundred men in the capital city were turned away because not enough physicians were available at a \u2018free circumcision Saturday\u2019 event.<\/p><\/blockquote>\n The authors are incredulous that there has been a delay in rolling out male circumcision on a broader scale.<\/p>\n So the question must be asked: why the continuing delays in the implementation of MC? Why do some prominent officials, nongovernmental organizations, Ministries of Health and international organizations vacillate as thousands become infected every day, preferring to debate over cultural imperialism, the \u2018rights\u2019 of the foreskin, the \u2018real world\u2019 validity of randomized trials and so on?<\/p>\n We understand the very real operational challenges, implementation logistics, safety concerns and the enormous task of scaling-up a surgical procedure so that it is readily available for millions of impoverished people.<\/p><\/blockquote>\n They make their own personal case:<\/p>\n Two of the authors (Wamai and Agot) are from Kenya and have witnessed first-hand the devastation in the part of the country (Nyanza Province) where the virus has flourished due in large part, we now realize, because that is the one province where MC is not a cultural norm. Another (Bowa) is a Zambian urologist who has struggled to make safe MC available at the University Teaching Hospital in Lusaka; due to funding limitations, the demand for services has far outstripped supply and the waiting list has grown up to 8 months long. Another (Kagimba) was one of the original architects of the now famous \u2018Zero Grazing\u2019 behavior change (partner reduction) strategy in Uganda, and seeks to add MC to the \u2018ABC\u2019 prevention approach.<\/p><\/blockquote>\n They conclude with a call for action:<\/p>\n Now, 25 years after the pandemic was first identified, we have an important additional tool, the knowledge to help bring life back, to give people some hope. We need the rallying cry; above all, we need accountability. We need you \u2013 the reader, the media, the viewer, the voter, the caring man or woman on the street \u2013 to say not whether but when. When will there be widespread, safe and affordable MC services available in Africa? Every day we are counting and watching.<\/p>\n Immediately, the front page of every major newspaper and other broadcast media around the world \u2013 certainly those in southern Africa \u2013 should report on the great impact that implementation of MC could bring.<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":" A January 2008 article in a new journal Future HIV Therapy makes the most persuasive case for male circumcision being rolled out on a much, much wider scale in sub-Saharan Africa. We have blogged about the importance of male circumcision before (see here, here, and here). This new piece is by Jeffrey D Klausner, Richard […]<\/p>\n","protected":false},"author":710,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1106,1107],"tags":[],"class_list":["post-214","post","type-post","status-publish","format-standard","hentry","category-epidemiology","category-politics-and-policy"],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts\/214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/users\/710"}],"replies":[{"embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/comments?post=214"}],"version-history":[{"count":3,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts\/214\/revisions"}],"predecessor-version":[{"id":241,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts\/214\/revisions\/241"}],"wp:attachment":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/media?parent=214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/categories?post=214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/tags?post=214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}