{"id":129,"date":"2006-12-13T15:39:56","date_gmt":"2006-12-13T20:39:56","guid":{"rendered":"http:\/\/blogs.law.harvard.edu\/politicshiv\/2006\/12\/13\/adult-male-circumcision-significa"},"modified":"2006-12-13T17:37:09","modified_gmt":"2006-12-13T22:37:09","slug":"adult-male-circumcision-significantly-reduces-risk-of-acquiring-hiv","status":"publish","type":"post","link":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/2006\/12\/13\/adult-male-circumcision-significantly-reduces-risk-of-acquiring-hiv\/","title":{"rendered":"E. African Male Circumcision Trials Halted for Ethical Reasons"},"content":{"rendered":"<p><em>Today from the National Institute of Allergy and Infectious Diseases<\/em><\/p>\n<blockquote><p><a href=\"http:\/\/www3.niaid.nih.gov\/news\/newsreleases\/2006\/AMC12_06.htm\"><font size=\"2\"><strong>&#8220;Trials in Kenya and Uganda Stopped Early&#8221;<\/strong><\/font><\/a><\/p>\n<p><a href=\"http:\/\/www3.niaid.nih.gov\/news\/newsreleases\/2006\/AMC12_06.htm\"><font size=\"2\" \/><\/a><font size=\"2\">The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced an early end to two clinical trials of adult male circumcision because an interim review of trial data revealed that medically performed circumcision significantly reduces a man\u2019s risk of acquiring HIV through heterosexual intercourse. The trial in Kisumu, Kenya, of 2,784 HIV-negative men showed a 53 percent reduction of HIV acquisition in circumcised men relative to uncircumcised men, while a trial of 4,996 HIV-negative men in Rakai, Uganda, showed that HIV acquisition was reduced by 48 percent in circumcised men.   <\/font><\/p>\n<p><font size=\"2\">\u201cThese findings are of great interest to public health policy makers who are developing and implementing comprehensive HIV prevention programs,\u201d says NIH Director Elias A. Zerhouni, M.D. \u201cMale circumcision performed safely in a medical environment complements other HIV prevention strategies and could lessen the burden of HIV\/AIDS, especially in countries in sub-Saharan Africa where, according to the 2006 estimates from UNAIDS, 2.8 million new infections occurred in a single year.\u201d<\/font><\/p>\n<p><font size=\"2\">&#8230;<\/font><\/p>\n<p><font size=\"2\">Both trials reached their enrollment targets by September 2005 and were originally designed to continue follow-up until mid-2007. However, at the regularly scheduled meeting of the NIAID Data and Safety Monitoring Board (DSMB) on December 12, 2006, reviewers assessed the interim data and deemed medically performed circumcision safe and effective in reducing HIV acquisition in both trials. They therefore recommended the two studies be halted early. All men who were randomized into the non-intervention arms will now be offered circumcision. <\/font><\/p>\n<p>&#8230;<br \/>\n<font size=\"2\" \/><\/p>\n<p><font size=\"2\"><font size=\"2\">For more information on the Kenyan and Ugandan trials of adult male circumcision, see the NIAID Questions and Answers document at <a target=\"_blank\" href=\"http:\/\/www3.niaid.nih.gov\/news\/QA\/AMC12_QA.htm\"> http:\/\/www3.niaid.nih.gov\/news\/QA\/AMC12_QA.htm<\/a>. <\/font><\/font><\/p>\n<p><font size=\"2\"><font size=\"2\">[<strong><a target=\"_blank\" href=\"http:\/\/www3.niaid.nih.gov\/news\/newsreleases\/2006\/AMC12_06.htm\">CLICK FOR COMPLETE ARTICLE<\/a><\/strong><\/font>]<br \/>\n<font size=\"2\" \/><\/font><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Today from the National Institute of Allergy and Infectious Diseases &#8220;Trials in Kenya and Uganda Stopped Early&#8221; The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced an early end to two clinical trials of adult male circumcision because an interim review of trial data revealed that [&hellip;]<\/p>\n","protected":false},"author":712,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1106],"tags":[],"class_list":["post-129","post","type-post","status-publish","format-standard","hentry","category-epidemiology"],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts\/129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/users\/712"}],"replies":[{"embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/comments?post=129"}],"version-history":[{"count":0,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/posts\/129\/revisions"}],"wp:attachment":[{"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/media?parent=129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/categories?post=129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/archive.blogs.harvard.edu\/politicshiv\/wp-json\/wp\/v2\/tags?post=129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}