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Neurosurgery and Neurology Grand Rounds, Oct 24th
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Neurosurgery-8:00 a.m.-Will Curry, Neurosurgery Resident, “Oncolytic Immunotherapy: Making Use of Danger”
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Neurology-9:00 a.m.-Michael Diringer, M.D. “Is there Ischemia Following Intracerebral hemorrhage” Director, NeuroICU, Barnes-Jewish Hospital, Washinton University Medical Center
From the literature…..
J Cereb Blood Flow Metab 2001 Jul;21(7):804-10
Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage.
Zazulia AR, Diringer MN, Videen TO, Adams RE, Yundt K, Aiyagari V, Grubb RL Jr, Powers WJ.
Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
The authors measured cerebral blood flow, the cerebral metabolic rate of oxygen, and the oxygen extraction fraction in 19 patients with intracerebral hemorrhage at time points ranging from 5 to 22 hours after hemorrhage onset. Both periclot CBF and CMR02 were reduced compared to mirror contralateral areas. CMR02 was reduced to a greater degree than CBF, yielding reduced OEF as compared to the increased OEF that occurs in ischemia.