EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE. [Neurosurgery – Current Table Of Contents] More data on angiogenesis in the U87 tumor model. U87, notably, tends to grow as a sphere in the brains of nude mice. It will be interesting to test this agent in other, more invasive models of glioma growth. There are ongoing clinical trials of this agent.